Named for city founder Wallace J. Williamson, Williamson Memorial Hospital opened in 1918.

Slightly more than a year after a Jan. 12, 1927, fire destroyed the facility, Williamson Memorial Hospital reopened on College Hill. Built at a cost of $175,000, the new facility grew to include 72 beds and 32 private rooms. Eventually, the emergency room, radiology department, laboratories and cafeteria were located on the bottom floor, the maternity unit on the second, medical and surgical rooms on the third and the pharmacy on the fourth.

Hospital Management Associates bought the hospital in 1979 and opened a new medical center on Alderson Street nine years later. The 60-year-old former hospital transitioned into a medical office and clinic complex and later was used for storage.

Shuttered amid the 2020 coronavirus pandemic, Williamson Memorial Hospital was purchased in 2020 by Williamson Health & Wellness Center under the leadership of CEO Dr. C. Donovan Beckett. Following extensive renovations, the addition of state-of-the-art equipment and more than $14 million in private and public investment, the new Williamson Memorial was licensed as a 76-bed general hospital in August 2024.